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The 1x CYP substrate cocktail contained phenacetin (10 M), bupropion (10 M), mephenytoin (50 M), diclofenac (10 M), bufuralol (10 M) and midazolam (5 M)

Dihexa is not currently regulated or banned by major doping agencies like WADA, but its novel mechanism and unapproved status underscore the need for careful clinical evaluation before widespread use

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Tanaka Y, Hirata S, Kubo S et al (2015) Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study

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